Meryl Streep did not get the lead role in the 1976 version of King Kong because the director said she was too ugly according to IOL. The Italian director Dino de Laurentis not only made the mistake of not hiring the future multi-award winner, but for thinking she wasn't as smart as she looks.
Streep says, "He said to his son, who organised the meeting, "She's ugly. Why did you bring me this thing.'
"He didn't realise I'd just graduated and studied Italian 105."
"When I replied in Italian, he looked like he had been shot."
I think Meryl did OK for herself and losing out on the role didn't effect her career.
Just in case you forgot or wondering who got the role, that was Jessica Lange.